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1

The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing

William G. Kaelin Jr.

Journal:

Biochemical and Biophysical Research Communications

Year:

2005

Language:

english

File:

PDF, 318 KB

english, 2005

2

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

William G. Kaelin Jr., Peter J. Ratcliffe

Journal:

Year:

2008

Language:

english

File:

PDF, 389 KB

english, 2008

3

Treatment of kidney cancer : Insights Provided by the VHL Tumor-Suppressor Protein

William G. Kaelin Jr

Journal:

Year:

2009

Language:

english

File:

PDF, 239 KB

english, 2009

4

10.1038/21710

Jost, Christine A., Marin, Maria C., Jr, William G. Kaelin

Journal:

Year:

1999

Language:

english

File:

PDF, 446 KB

english, 1999

5

ROS: Really involved in Oxygen Sensing

William G. Kaelin Jr.

Journal:

Cell Metabolism

Year:

2005

Language:

english

File:

PDF, 83 KB

english, 2005

6

The von Hippel–Lindau tumor suppressor protein

Mircea Ivan, William G Kaelin Jr

Journal:

Current Opinion in Genetics & Development

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001

7

The von Hippel–Lindau tumor suppressor protein: new insights into oxygen sensing and cancer

William Kim, William G Kaelin Jr

Journal:

Current Opinion in Genetics & Development

Year:

2003

Language:

english

File:

PDF, 354 KB

english, 2003

8

Functions of the retinoblastoma protein

William G. Kaelin Jr.

Journal:

Year:

1999

Language:

english

File:

PDF, 182 KB

english, 1999

9

Innovations and challenges in renal cancer: Summary statement from the Third Cambridge Conference

Michael B. Atkins, Ronald M. Bukowski, Bernard J. Escudier, Robert A. Figlin, Gary H. Hudes, William G. Kaelin Jr, W. Marston Linehan, David F. McDermott, James W. Mier, Ivan Pedrosa, Brian I. Rini, S

Journal:

Year:

2009

Language:

english

File:

PDF, 104 KB

english, 2009

10

Alterations in G1/S Cell-Cycle Control Contributing to Carcinogenesis

WILLIAM G. KAELIN JR.

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 284 KB

english, 1997

11

New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein

William G. Kaelin, Jr.

Journal:

Annals of the New York Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 225 KB

english, 2010

12

10.1038/35036614

Kaelin Jr, William G., Irwin, Meredith, Marin, Maria Carmen, Phillips, Andrew C., Seelan, Ratnam S., Smith, David I., Liu, Wanguo, Flores, Elsa R., Tsai, Kenneth Y., Jacks, Tyler, Vousden, Karen H.

Journal:

Year:

2000

Language:

english

File:

PDF, 179 KB

english, 2000

13

10.1038/38298

Jr, William G. Kaelin, Jost, Christine A., Marin, Maria C.

Journal:

Year:

1997

Language:

english

File:

PDF, 390 KB

english, 1997

14

The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

Kaelin Jr, William G.

Journal:

Nature Reviews Cancer

Year:

2008

Language:

english

File:

PDF, 553 KB

english, 2008

15

A Conserved Region of Unknown Function Participates in the Recognition of E2F Family Members by the Adenovirus E4 ORF 6/7 Protein

CHRISTINE A. JOST, DORON GINSBERG, WILLIAM G. KAELIN, JR.

Journal:

Year:

1996

Language:

english

File:

PDF, 560 KB

english, 1996

16

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

James Brugarolas, William G Kaelin Jr.

Journal:

Year:

2004

Language:

english

File:

PDF, 109 KB

english, 2004

17

The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase

Wenyi Wei, Jianping Jin, Susanne Schlisio, J. Wade Harper, William G. Kaelin Jr.

Journal:

Year:

2005

Language:

english

File:

PDF, 615 KB

english, 2005

18

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer

Sungwoo Lee, Eijiro Nakamura, Haifeng Yang, Wenyi Wei, Michelle S. Linggi, Mini P. Sajan, Robert V. Farese, Robert S. Freeman, Bruce D. Carter, William G. Kaelin Jr., Susanne Schlisio

Journal:

Year:

2005

Language:

english

File:

PDF, 887 KB

english, 2005

19

Kidney Cancer: Now Available in a New Flavor

William G. Kaelin Jr.

Journal:

Year:

2008

Language:

english

File:

PDF, 171 KB

english, 2008

20

SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling

William G. Kaelin Jr.

Journal:

Year:

2009

Language:

english

File:

PDF, 173 KB

english, 2009

21

Prostate Cancer: Beta Control Your Hormones

Massimo Loda, William G. Kaelin Jr.

Journal:

Year:

2010

Language:

english

File:

PDF, 113 KB

english, 2010

22

The VHL tumour-suppressor gene paradigm

William G Kaelin Jr, Eamonn R Maher

Journal:

Trends in Genetics

Year:

1998

Language:

english

File:

PDF, 272 KB

english, 1998

23

p63 and p73: old members of a new family

Maria C Marin, William G Kaelin Jr.

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2000

Language:

english

File:

PDF, 266 KB

english, 2000

24

The von Hippel–Lindau tumour suppressor protein: new perspectives

Michael Ohh, William G. Kaelin Jr.

Journal:

Molecular Medicine Today

Year:

1999

Language:

english

File:

PDF, 267 KB

english, 1999

25

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

Keiichi Kondo, Jeff Klco, Eijiro Nakamura, Mirna Lechpammer, William G Kaelin Jr.

Journal:

Year:

2002

Language:

english

File:

PDF, 490 KB

english, 2002

26

Chemosensitivity linked to p73 function

Meredith S Irwin, Keiichi Kondo, Maria Carmen Marin, Lynn S Cheng, William C Hahn, William G Kaelin Jr.

Journal:

Year:

2003

Language:

english

File:

PDF, 651 KB

english, 2003

27

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

James B Brugarolas, Francisca Vazquez, Archana Reddy, William R Sellers, William G Kaelin Jr.

Journal:

Year:

2003

Language:

english

File:

PDF, 662 KB

english, 2003

28

Molecular Pathways in Renal Cell Carcinoma—Rationale for Targeted Treatment

William Y. Kim, William G. Kaelin Jr

Journal:

Seminars in Oncology

Year:

2006

Language:

english

File:

PDF, 323 KB

english, 2006

29

The von Hippel–Lindau Tumor Suppressor Gene

Keiichi Kondo, William G. Kaelin Jr.

Journal:

Experimental Cell Research

Year:

2001

Language:

english

File:

PDF, 85 KB

english, 2001

30

Systemic lupus erythematosus and myelofibrosis

William G. Kaelin Jr., Jerry L. Spivak

Journal:

The American Journal of Medicine

Year:

1986

Language:

english

File:

PDF, 1.55 MB

english, 1986

31

Structure and partial genomic sequence of the human E2F1 gene

Elizabeth Neuman, William R. Sellers, John A. McNeil, Jeanne B. Lawrence, William G. Kaelin Jr.

Journal:

Year:

1996

Language:

english

File:

PDF, 834 KB

english, 1996

32

The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase

Robert J. Klose, Qin Yan, Zuzana Tothova, Kenichi Yamane, Hediye Erdjument-Bromage, Paul Tempst, D. Gary Gilliland, Yi Zhang, William G. Kaelin Jr.

Journal:

Year:

2007

Language:

english

File:

PDF, 829 KB

english, 2007

33

Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation

Elizaveta V. Benevolenskaya, Heather L. Murray, Philip Branton, Richard A. Young, William G. Kaelin Jr.

Journal:

Year:

2005

Language:

english

File:

PDF, 716 KB

english, 2005

34

pVHL Acts as an Adaptor to Promote the Inhibitory Phosphorylation of the NF-κB Agonist Card9 by CK2

Haifeng Yang, Yoji Andrew Minamishima, Qin Yan, Susanne Schlisio, Benjamin L. Ebert, Xiaoping Zhang, Liang Zhang, William Y. Kim, Aria F. Olumi, William G. Kaelin Jr.

Journal:

Year:

2007

Language:

english

File:

PDF, 1.40 MB

english, 2007

35

A Role for Mammalian Sin3 in Permanent Gene Silencing

Chris van Oevelen, Jinhua Wang, Patrik Asp, Qin Yan, William G. Kaelin Jr., Yuval Kluger, Brian David Dynlacht

Journal:

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

36

Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues

Christopher L Corless, Adam S Kibel, Othon Iliopoulos, William G Kaelin Jr

Journal:

Human Pathology

Year:

1997

Language:

english

File:

PDF, 3.87 MB

english, 1997

37

E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation

Seth J Field, Fong-Ying Tsai, Frank Kuo, Ana M Zubiaga, William G Kaelin Jr., David M Livingston, Stuart H Orkin, Michael E Greenberg

Journal:

Year:

1996

Language:

english

File:

PDF, 1.43 MB

english, 1996

38

Rapid and durable recovery of visual function in a patient with von hippel-lindau syndrome after systemic therapy with vascular endothelial growth factor receptor inhibitor su5416

Lloyd Paul Aiello, Daniel J George, Mark T Cahill, Jun S Wong, Jerry Cavallerano, Alison L Hannah, William G Kaelin Jr

Journal:

Year:

2002

Language:

english

File:

PDF, 383 KB

english, 2002

39

Negative control elements of the cell cycle in human tumors

Peter D Adams, William G Kaelin Jr

Journal:

Current Opinion in Cell Biology

Year:

1998

Language:

english

File:

PDF, 773 KB

english, 1998

40

The von Hippel-Lindau Tumor Suppressor Protein Is Required for Proper Assembly of an Extracellular Fibronectin Matrix

Michael Ohh, Robert L. Yauch, Kim M. Lonergan, Jean M. Whaley, Anat O. Stemmer-Rachamimov, David N. Louis, Brian J. Gavin, Nikolai Kley, William G. Kaelin Jr., Othon Iliopoulos

Journal:

Year:

1998

Language:

english

File:

PDF, 398 KB

english, 1998

41

Using cancer genetics to guide the selection of anticancer drug targets

Archana Reddy, William G Kaelin Jr

Journal:

Current Opinion in Pharmacology

Year:

2002

Language:

english

File:

PDF, 93 KB

english, 2002

42

Clusterin Is a Secreted Marker for a Hypoxia-Inducible Factor-Independent Function of the von Hippel-Lindau Tumor Suppressor Protein

Eijiro Nakamura, Paula Abreu-e-Lima, Yasuo Awakura, Takahiro Inoue, Toshiyuki Kamoto, Osamu Ogawa, Hirokazu Kotani, Toshiaki Manabe, Guo-Jun Zhang, Keiichi Kondo, Vānia Nosé, William G. Kaelin Jr

Journal:

The American Journal of Pathology

Year:

2006

Language:

english

File:

PDF, 1.55 MB

english, 2006

43

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

William G. Kaelin Jr., David C. Pallas, James A. DeCaprio, Frederic J. Kaye, David M. Livingston

Journal:

Year:

1991

Language:

english

File:

PDF, 4.51 MB

english, 1991

44

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

Thomas Chittenden, David M. Livingston, William G. Kaelin Jr.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.69 MB

english, 1991

45

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

William G. Kaelin Jr., Wilhelm Krek, William R. Sellers, James A. DeCaprio, Florence Ajchenbaum, Charles S. Fuchs, Thomas Chittenden, Yue Li, Peggy J. Farnham, Michael A. Blanar, David M. Livingston,

Journal:

Year:

1992

Language:

english

File:

PDF, 3.11 MB

english, 1992

46

Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase

Wilhelm Krek, Mark E. Ewen, Suman Shirodkar, Zoltàn Arany, William G. Kaelin Jr., David M. Livingston

Journal:

Year:

1994

Language:

english

File:

PDF, 4.05 MB

english, 1994

47

von Hippel–Lindau-associated malignancies: Mechanisms and therapeutic opportunities

William G. Kaelin Jr

Journal:

Drug Discovery Today: Disease Mechanisms

Year:

2005

Language:

english

File:

PDF, 245 KB

english, 2005

48

Selective Killing of Transformed Cells by Cyclin/Cyclin-Dependent Kinase 2 Antagonists

Ying-Nan P. Chen, Sushil K. Sharma, Timothy M. Ramsey, Li Jiang, Mary S. Martin, Kayla Baker, Peter D. Adams, Kenneth W. Bair and William G. Kaelin, Jr.

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.24 MB

english, 1999

49

pVHL19Is a Biologically Active Product of the von Hippel-Lindau Gene Arising from Internal Translation Initiation

Othon Iliopoulos, Michael Ohh and William G. Kaelin, Jr.

Journal:

Proceedings of the National Academy of Sciences

Year:

1998

Language:

english

File:

PDF, 1.26 MB

english, 1998

50

Synthetic lethality: a framework for the development of wiser cancer therapeutics

William G Kaelin Jr

Journal:

Genome Medicine

Year:

2009

Language:

english

File:

PDF, 330 KB

english, 2009

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